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Ergotamine vs Ergometrine

Ergotamine Ergometrine
Peptide alkaloid Amine alkaloid
Polypeptide chain present Polypeptide chain absent
Powerful antagonist on alpha receptor and partial agonist Mild agonist on alpha receptor
No effect on dopamine receptor Mild effect on dopamine receptor
Partial agonist on serotonin receptor Partial agonist and antagonist on serotonin receptors
Less effect on uterus More effect on uterus
Blood vessels

Endothelial damage

Potent vasoconstriction

 

No damage

Less vasoconstriction

Miosis (alpha blocked) Mydriasis (alpha agonist)

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