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Structure related to Acetylcholine, acetate is replaced by carbamate & choline is methylated, thus it is carbomyl beta methyl choline.
It has no nicotinic actions
Muscarinic actions are prominent on eye, GIT & urinary bladder
Prolonged duration of action because is more resistant to hydrolysis.
Duration of action is one hour.
Therapeutic uses:
1. Post operative gastric distension
2. Paralytic ileus
3. Bladder atonia
4. Megacolon
It is given subcutaneously in 5 mg dose. Neostigmine is also given for these conditions (15 mg oral, 0.5-1 mg subcutaneously)
Mechanism of action is like carbamates.
Toxicity includes bronchospasm, it does not enter CNS.
