howMed Know Yourself
The clinical uses of antidepressants include the following: 1. Depression Mild to moderate. Normally advised psychotherapy, cognitive, behavior therapy. If … Read More »
Monoamine Oxidase Inhibitors
Chemistry Hydrazine derivative –Phenelzine/Isocarboxazid Non-hydrazine derivatives –rest all Tranylcypromine also has amphetamine like activity Pharmacokinetics Monoamine oxidase is present in … Read More »
5HT2 Antagonists and Tetracyclic Unicyclic Antidepressants
5-HT2 antagonists Chemically triazole moiety, having antidepressant effect. Pharmacokinetics Well absorbed after oral administration. Extensive plasma protein binding Extensively metabolized … Read More »
Serotonin Norepinephrine Reuptake Inhibitors
Selective SNRIs Chemistry Venlafaxine / Desvenlafaxine – bicyclic Duloxetine – 3-ring Milnacipran – cyclopropane ring Pharmacokinetics Well … Read More »
Selective Serotonin Reuptake Inhibitors
Chemistry Different chemical structure. Fluoxetine / sertraline / citalopram have enantiomers R and S, formulated as racemic products Escitalopram S … Read More »
Anti Depressant Agents
Depression “Mental disorder that presents with depressed mood, loss of interest or pleasure, feeling of guilt or low self-worth, disturbed … Read More »
Lithium
Lithium is a monovalent cation used in manic psychosis. Three salts are available: Lithium carbonate Lithium citrate Lithium chloride Lithium … Read More »
Antipsychotic Drugs
Classification of Antipsychotic Drugs 1. Typical Antipsychotics (Old generation) Tricyclic Antipsychotics Phenothiazines a. Aliphatic (least used) Chlorpromazine b. Piperidine Thioridazine … Read More »
Psychiatric Problems
Psychiatric diseases are quite different from other diseases of body. Some very important symptoms of these illnesses are: Hallucinations Hallucinations … Read More »
Barbiturates
Introduction Barbiturates were used as sedative/hypnotic for a long time. Now non-preferred because of: Non-selective depression of CNS Low therapeutic … Read More »