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Chemotherapy and Radiation

Role of chemotherapy

  • As primary curative therapy.
  • As adjuvant treatment.
  • As neo adjuvant treatment.
  • As palliative chemotherapy for advanced disease.

OBJECTIVES

CURATIVE TREATMENT
a) Non Hodgkin’s lymphoma

b) Hodgkin’s disease

c) Testicular tumours

d) Gestational trophoblastic diseases

e) Small cell carcinoma

f) Ewing sarcoma

g) Osteo sarcoma

h) Acute leucaemia

NEO ADJUVANT CHEMOTHERAPY ( to downstage the tumour and make organ and limb  saving surgery possible)

a) Osteo sarcoma

b) Carcinoma breast

c) Colorectal cancers

d) Head and neck cancers

ADJUVANT CHEMOTHERAPY

( for prevention of recurrence after surgery)

a) Carcinoma breast

b) Colorectal cancers

c) Carcinoma ovary

d) Carcinoma lung

e) Head and neck cancers

f) Osteo sarcoma

PALLIATIVE CHEMOTHERAPY It is used in advanced and incurable cancers to slow down the progress of disease and to achieve pain control

COMMON CANCERS

PROSTATE / BREAST

LUNG

COLORECTAL

BLADDER / UTERUS / OVARY

NHL

MELANOMA

HEAD & NECK

KIDNEY

LEUKAEMIAS

PANCREAS

CURABLE CANCERS IN ADVANCED STAGE

CHEMOTHERAPY DRUGS

First line and commonly used drugs to be made available so as to start treatments immediately after diagnosis

Drug groups

  1. First line and commonly used drugs to be made available so as to start treatments immediately after diagnosis
  2. agents (cyclophosphamide)
  3. Antimetabolites (methotrexate)
  4. Antitumour antibiotics (bleomycin)
  5. Mitotic spindle agents (taxols)
  6. Topoisomerse inhibitors (etoposide)
  7. Others (l- asparaginase)
  8. Hormones: (steroids, ER blockers etc)

RADIATION

MODE OF RADIATION

1.  TELETHERAPY(ERBT)

2.  BRACHYTHERAPY

3.  3D – CRT / IMRT

4.  GAMMA KNIFE RADIOSURGERY

5.  CYBERKNIFE

OBJECTIVES OF RADIATION

1.  CURATIVE

2.  CONSOLIDATION

3.  MEO ADJUVANT

4.  ADJUVANT

5.  PALLIATIVE

FIELDS OF RADIATION

1.  INVOLVED FIELD(IF)

2.  EXTENDED FIELD(EF)

3.  MENTAL FIELD(MF)

4.  INVERTED Y

5.  DOG LEG

Also see

Acute Leukemia

Chronic Leukemia

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