Structure related to Acetylcholine, acetate is replaced by carbamate & choline is methylated, thus it is carbomyl beta methyl choline.
It has no nicotinic actions
Muscarinic actions are prominent on eye, GIT & urinary bladder
Prolonged duration of action because is more resistant to hydrolysis.
Duration of action is one hour.
1. Post operative gastric distension
2. Paralytic ileus
3. Bladder atonia
It is given subcutaneously in 5 mg dose. Neostigmine is also given for these conditions (15 mg oral, 0.5-1 mg subcutaneously)
Mechanism of action is like carbamates.
Toxicity includes bronchospasm, it does not enter CNS.