Flumazenil is a benzodiazepine antagonist, which also binds the same receptors as benzodiazepines.
Has high affinity for benzodiazepine receptor
It behaves as a Competitive antagonist.
It is used as antidote to benzodiazepine overdose.
The sedative effects of benzodiazepines are antagonized.
It is given parentally for symptomatic treatment, producing immediate effects and has a short half life.
If over dosage of long acting benzodiazepine occurs, we have to repeat dose of flumazenil, due to its short half life.
- Precipitation of abstinence syndrome in patients with benzodiazepine dependence
- Nausea with repeated dose