Mephenesin acts by decreasing the transmission in polysynaptic pathway. It produces muscle relaxant effects. It can be used in:
1. Strychnine over dosage
Adverse effects include sedation and drowsiness.
Dose is 1-3 grams daily in divided doses.
Meprobamate is less commonly used because of strong sedative effects which hinders normal activities of individual. It is an enzyme inducer and can interact with various drugs.
It is contraindicated in porphyria.
Skeletal Muscle Relaxants
Tubocurarine -Non-depolarizing Neuromuscular Blocker
Atracurium, Cisatracurium, Gallamine and Steroid Derivatives -Non Depolarizing Neuromuscular Blockers
Suxamethonium -Depolarizing Neuromuscular Blocker
Factors affecting actions of Neuromuscular blockers
Benzodiazepines as Centrally Acting Skeletal Muscle Relaxants
Baclofen and Progabide -GABA Analogues
Cyclobenzaprine, Orphenadrine and Tizanidine
Dantrolene -Directly Acting Skeletal Muscle Relaxant
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