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Nicotine and Lobeline

Alkaloids liquid in nature, obtained from plant source.

Actions are mainly on nicotinic receptors (CNS, PNS, NMJ)

Effects

CNS, have important effects on brainstem and cortex.

PNS – autonomic ganglia.

NMJ, immediate depolarization of the end plate – increase in permeability to sodium and potassium ions.

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