Physostigmine

Natural alkaloid obtained from “Physostigma Venenosum”. It is a tertiary amine derivative, crosses blood brain barrier and is highly lipid soluble, penetrating membranes of body.

Use:

1. Treatment in glaucoma, not first line drug.

2. Also effective in atropine poisoning

3. Over dosage of anti depressant drugs

4. As crosses BBB, it is only reserved for special intoxication conditions.

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Anticholinesterases

Neostigmine

Pyridostigmine, Edrophonium and Echothiophate

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