The main drug is amiodarone, which is most commonly used as antiarrhythmic. It is effective in a wide range of arrhythmias.
Mechanism of Action
It mainly acts by blocking K+ channels. It increases the refractory period. It increases the duration without effecting phase 0 and resting membrane potential.
There are two types of K+ channels:
b. I Ks
Inward potassium current or rectifier also called delayed potassium currents. 2 components are:
a. Rapid component -IKr
b. Slow component – I Ks
The drug acts mainly by blocking IKr. Chronic administration also affects I Ks , It blocks K+ channels. Also have some effects on alpha and beta receptors, blocking them non-competitively, having a small effect.
Drug is rapidly absorbed after oral route of administration. It has high volume of distribution (greater tissue binding). Since it is highly lipid soluble, it tends to deposit in the tissues, especially adipose tissue. It is metabolized in the liver and excreted in bile. It is slowly released from the tissue binding sites. Half life is longer (about 30 days, may even be up to 100 days).
- Drug has broad antiarrhythmic effect (esp. ventricular arrhythmias)
- Supraventricular arrhythmias
- Reentrant tachycardia –as prolongs refractory period.
Since the drug causes prolongation of refractory period
- QT interval is prolonged
- Because of resemblance with thyroxine, drug may interfere with functions of thyroid, causing hypo or hyperthyroidism.
- As has greater Vd, it gets bound and deposited in cornea, leading to visual problems and photophobia.
- Has tendency to deposit in skin, may sensitize it to sunlight. Bluish discoloration occurs on exposed parts on prolonged administration (due to iodine content).
- On prolonged administration pulmonary fibrosis might occur
- Hepatic damage might occur as is metabolized in the liver.
- With digoxin, plasma conc. of digoxin increases
- Warfarin, similar to digoxin
- With beta blockers and Ca++ channel blockers –both cause depression of heart, causing hypotension and bradycardia.
Start at loading dose, first given 200 mg for 1 week (twice daily). Maintenance dose is 200 mg once daily.
Bretylium is adrenergic neuron blocker and sympatholytic drug. It acts by inhibiting release of NE from adrenergic nerve terminals. It is mainly used for treatment of refractory ventricular arrhythmias esp. after MI and during surgery.
Sotalol is a beta blocker with class III properties. It prolongs the refractory period and action potential. It is commonly used.