howMed Know Yourself
Electrophysiological Properties of heart 1. Automaticity Automaticity is the property of the heart by which impulses are formed spontaneously. Impulses … Read More »
Dantrolene -Directly Acting Skeletal Muscle Relaxant
Chemistry Chemically dantrolene is hydantoin derivative. Mechanism of Action It decreases the release of calcium from sarcoplasmic reticulum by binding … Read More »
Cyclobenzaprine, Orphenadrine and Tizanidine
Cyclobenzaprine It mainly acts at the level of brainstem. It has anticholinergic effect and is a good muscle relaxant. It … Read More »
Mephenesin and Meprobamate -Propandiol Derivatives
Mephenesin Mephenesin acts by decreasing the transmission in polysynaptic pathway. It produces muscle relaxant effects. It can be used in: … Read More »
Baclofen and Progabide -GABA Analogues
Baclofen Baclofen acts as agonist at GABA receptors especially GABA B receptors. Ultimately there is hyper polarization due to: Increased … Read More »
Benzodiazepines as Centrally Acting Skeletal Muscle Relaxants
Centrally acting muscle relaxants Effects They produce effects centrally in brain or spinal cord. Decrease spasm They are used to … Read More »
Factors affecting actions of Neuromuscular blockers
Several factors influence the action of neuromuscular blockers, these include: 1. Blood flow to muscles If blood flow is rapid, … Read More »
Suxamethonium -Depolarizing Neuromuscular Blocker
Suxamethonium is the only drug used in the category of depolarizing neuromuscular blockers and is synthetic, consisting of 2 molecules … Read More »
Atracurium, Cisatracurium, Gallamine and Steroid Derivatives -Non Depolarizing Neuromuscular Blockers
Atracurium Actions are similar to those of d-tubocurarine. It is safer and more potent than d-tubocurarine because It is eliminated … Read More »
Tubocurarine -Non-depolarizing Neuromuscular Blocker
Tubocurarine is a non-depolarizing neuromuscular blocker. Non-depolarizing neuromuscular blockers interfere with the NM transmission. D-tubocurarine is a natural substance, obtained … Read More »