howMed Know Yourself
Cholesterol Absorption Inhibitors Exetimibe It interferes with absorption of cholesterol and phytosterols in small intestine by interfering with a transport … Read More »
Probucol and Nicotinamides
Probucol Butylated hydroxytoluene, not commonly used. It is used only in individuals who do not respond to other drugs. Decrease … Read More »
Bile Acid binding resins
Basic ion exchange resins, supplied in chloride form. They are neither digested nor absorbed and basically decrease LDL levels. This … Read More »
Fibric acid Derivatives
Clofibrate Clofibrate is the 1st drug discovered, but rarely used because of toxic effects. Better drugs with less toxicity and … Read More »
HMG CoA Reductase Inhibitors
Source Lovastatin and Mevastatin are obtained from natural source, from micro-organisms, penicillin and micromonosporas. Pravastatin and Simvastatin are semi-synthetic drugs. … Read More »
Hypolipidemic Drugs
Drugs that lower lipid and lipoproteins levels in the blood are known as hypolipidemic drugs. The first measure in controlling … Read More »
Thrombolytics and Fibrinolytics
As the name suggests these drugs: a. break down thrombosis – Arterial / Venous b. Fibrinolysis –degrade fibrinogen and fibrin … Read More »
Antiplatelet Drugs
Antiplatelet drugs affect the fluidity of blood in thromboembolic conditions. Platelet Plug Normally when endothelial injury occurs, it exposes tissues … Read More »
Warfarin
History During early 20th century, hemorrhagic diseases occurred in cattle that ate spoiled fodder (spoiled sweet clover silage). Chemists at … Read More »
Fondaparinux, Heparinoids and Direct Thrombin Inhibitors
Fondaparinux Chemistry – synthetic pentasacchride Mechanism of Action Acts by inhibiting factor X. Pharmacokinetics Long half life of 17-21 hours. … Read More »