howMed Know Yourself
Flumazenil is a benzodiazepine antagonist, which also binds the same receptors as benzodiazepines. Has high affinity for benzodiazepine receptor It … Read More »
Benzodiazepines
Structure of Benzodiazepines Benzene ring (A) Seven member diazepine ring (B) 5 aryl substitution ring Chemically known as 5-aryl 1,4 … Read More »
Sedatives and Hypnotics -An Introduction
Sedatives and hypontics are the most desired drugs. Sedation Decreased responsiveness to a constant level of stimulation.(Psychomotor retardation) Reduced excitation, … Read More »
Acetazolamide, Sulthiame and Newer Antiepileptics
Acetazolamide Not commonly used for treatment of epilepsy. Only effect is due to acidosis produced, being more effective in petit … Read More »
Benzodiazepines as Antiepileptics
Benzodiazepines acting as antiepileptics are: Clonazepam Nitrazepam Diazepam Mechanism of action Mainly act for control of seizures on three parts … Read More »
Phenobarbitone, Methobarbitone, Primidone and Succinamides
Barbiturates Main drug is phenobarbitone, which was first used as antiepileptic. Chemistry Derivatives of barbituric acid Mechanism of action –In … Read More »
Valproic Acid
Valproic acid is a derivative of carboxylic acid. Mechanism of action Drug acts by inhibiting enzymes responsible for breakdown of … Read More »
Carbamazepine and Oxcarbamazepine
Carbamazepine Chemically related to tricyclic antidepressant drug Imipramine. Mechanism of action Similar effects as phenytoin. Blocks Na channels and prevents … Read More »
Phenytoin Sodium
Mechanism Of Action of Phenytoin Acts by various mechanisms. Membrane stabilizing effect Most important, as belongs to sodium channel blockers, … Read More »
Antiepileptic Drugs
Antiepileptic drugs may be classified as follows: Classification (Chemical) Hydantoin derivatives Phenytoin Fosphenytoin Iminostilbenes Carbamazepine (only antiepileptic used in pregnancy) … Read More »