Apraclonidine

It is topically used in the eye as eye drops, it does not cross blood brain barrier, and is given in low doses so there are less chances of hypertension.

It decreases intraocular pressure by:

1. Decreasing production of aqueous humor
2. Increasing outflow of aqueous humor

It is protective to neural tissue, thus possibly has some role in treatment of glaucoma.

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Central Sympathoplegics and Alpha Methyl Dopa

Clonidine

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