howMed Know Yourself
Hyperuricemia The causes of hyperuricemia may be primary or secondary. Primary Overproduction: Idiopathic Lesch-Nyhan syndrome Glucose-6-phosphatase deficiency Reduced excretion: Idiopathic … Read More »
Causes of Hyperuricemia and Hypouricemia
Inborn Errors of Purine Metabolism
Inborn errors of purine metabolism include the following: 1. Hypoxanthine-guanine phosphoribosyl transferase Severe deficiency (Lesch-Nyhan syndrome) The Lesch-Nyhan syndrome is … Read More »
Gout -Stages, Diagnosis and Investigations
Gout is a group of metabolic diseases associated with hyperuricaemia and deposition of crystals of monosodium urate in tissues. Presentation … Read More »
Differential Diagnosis of Joint Pain
Differential diagnosis of joint pain includes the following: Traumatic Causes Bones Patellar fractures Supracondylar fractures of femur Tibial fractures involving … Read More »
Monitoring Reperfusion after Thrombolytic Therapy
Early monitoring of markers may be useful to determine reperfusion success in patients receiving thrombolytic therapy. The complete opening of … Read More »
Investigations of Acute Coronary Syndrome
Laboratory investigations (Other than cardiac markers) Plasma glucose- fasting and after break fast (ABF) HBA1c (glycosylated haemoglobin) Microalbuminaemia (spot urine … Read More »
Cardiac Markers and their Pattern of Release
A cardiac marker is a clinical laboratory test that is useful in the detection of acute myocardial infarction or minor … Read More »
Diagnosis of Myocardial Infarction
WHO criteria for diagnosis of acute myocardial infarction World Health Organization required at least two of the following criteria: (1) … Read More »
Acute Myocardial Infarction -Pathophysiology and Precipitating Factors
Coronary Artery Disease (CAD) is a complete succession of events that starts with endothelial dysfunction, lipid accumation and migration of … Read More »
Nephrotic Syndrome -Causes, Diagnosis and Treatment
Nephrotic syndrome is characterized by excessive glomerular permeability to plasma proteins (proteinuria more than 3.5 g per day). Depending on … Read More »