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Humoral Immunity |
Cell mediated Immunity |
|
| Main cells | B lymphocytes | T lymphocytes |
| Maturation | Generated and matured in bone marrow | Originate in bone marrow and complete development in thymus |
| Protect against | Extracellular microbes and their toxins
|
Intracellular microbes
|
| %age of lymphocytes | 10-20% circulating peripheral lymphocyte population | 60-70% |
| Location in lymph nodes | Superficial cortex | Paracortical areas |
| Location in spleen | White pulp | Periarteriolar sheaths |
| Receptors | B-cell antigen receptor complex consisting of mainly IgM and IgD immunoglobulins | In 95% T cells à alpha/beta TCR
In minority à gamma, T cells |
| Accessory surface molecules | Igα, Igβ, Fc receptors, CD40, CD21 | CD3 molecular complex
Dimer of ∑ chain CD4, CD8, CD2, CD28 integrins |
| End result of activation | Differentiation of B cells into antibody secreting cells called plasma cells | Secrete locally acting proteins called cytokines |
| Hypersensitivity reactions | I, II, III are antibody mediated | IV is cell mediated |
| Role of MHC molecules | Antigen receptor recognizes whole unprocessed proteins and has no requirement for presentation by MHC protein | Antigen receptor recognizes only processed peptides in association with MHC protein |
| Regulator of antibody synthesis | No | Yes |
| Onset | Rapid | Delayed type hypersensitivity |
| Antibodies | Formed | Not formed |
| Evaluation | From plasma level of antibodies | Skin test for development of delayed type of hypersensitivity |
| Cells involved | Ab synthesis requires 3 cells:
|
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Nice +precise tabular comparison…… thank u ……..