Differences Between Crohn’s Disease and Ulcerative Colitis

S/N		Crohn’s Disease	Ulcerative Colitis
1	Involvement of Wall	Transmural	Confined to mucosa and submucosa
2	Thickness of Wall	Thick wall	Only mucosa thick, rest of the wall is thin
3	Limited to colon	No	Yes
4	Granuloma formation	Yes	No
5	Fistulae	Yes	Rarely
6	Ileum involvement	Most commonly affect terminal ileum	Rarely involve ileum
7	Skip lesions	Yes	No
8	Crypt Abcesses	Uncommonly	Commonly
9	Pseudopolyps	Present moderately	Presence is well marked.
10	Strictures	Yes	No
11	Ulcers	Deep(Knife like)	Superficial with broad base.
12	Lymphocytic reaction	Well marked	Mild
13	Fibrosis	Well-marked	Mild
14	Serositis	Common	Rare
15	Malabsorption	Yes	No