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Differences Between Crohn’s Disease and Ulcerative Colitis

Crohn’s Disease
Ulcerative Colitis
1 Involvement of Wall Transmural Confined to mucosa and submucosa
2 Thickness of Wall Thick wall Only mucosa thick, rest of the wall is thin
3 Limited to colon No Yes
4 Granuloma formation Yes No
5 Fistulae Yes Rarely
6 Ileum involvement Most commonly affect terminal ileum Rarely involve ileum
7 Skip lesions Yes No
8 Crypt Abcesses Uncommonly Commonly
9 Pseudopolyps Present moderately Presence is well marked.
10 Strictures Yes No
11 Ulcers Deep(Knife like) Superficial with broad base.
12 Lymphocytic reaction Well marked Mild
13 Fibrosis Well-marked Mild
14 Serositis Common Rare
15 Malabsorption Yes No


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