Baclofen acts as agonist at GABA receptors especially GABA B receptors. Ultimately there is hyper polarization due to:
- Increased potassium conductance
- Decreased release of excitatory neurotransmitters
- Decreased release of subs P
- Musculoskeletal disorders
- Muscle spasms
Dose is 15 mg, which can be increased to 100 mg.
Progabide is a less commonly used muscle relaxant acting at both GABA A and GABA B receptors. It produces muscle relaxant effects because of active metabolite.