Baclofen and Progabide -GABA Analogues

Baclofen

Baclofen acts as agonist at GABA receptors especially GABA B receptors. Ultimately there is hyper polarization due to:

1. Increased potassium conductance
2. Decreased release of excitatory neurotransmitters
3. Decreased release of subs P

Uses

1. Musculoskeletal disorders
2. Neuralgia
3. Muscle spasms

Adverse effects

1. Confusion
2. Sedation
3. Drowsiness
4. Weakness
5. Fatigue
6. Hypotonia

Contraindications

Psychiatric illness

Dose

Dose is 15 mg, which can be increased to 100 mg.

Progabide

Progabide is a less commonly used muscle relaxant acting at both GABA A and GABA B receptors. It produces muscle relaxant effects because of active metabolite.

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